Alternative Names: Vaccine injury

Causes, incidence, and risk factors:

Symptoms:

NORMAL REACTION TO DTaP IMMUNIZATION

• Mild fever
• Irritability
• Localized tenderness and swelling at site of injection

ABNORMAL REACTION TO DTaP IMMUNIZATION

• Unrelieved crying
• High-pitched cry
• Unusual shock-like syndrome
  • Unresponsiveness
  • Hypotonia (limp/decreased tone)
• Marked increase in sleeping time
• Persistent high fever (104 degrees Fahrenheit or greater)
• Seizure or convulsion

NORMAL REACTION TO MMR

• Fever up to 103 degrees about 7-10 days after vaccine administration
• Mild measles rash (reaction to measles vaccine)
• Transient joint pains (reaction to rubella vaccine)

REACTIONS INCORRECTLY ATRIBUTED TO MMR

Several anti-vaccine groups have attributed the rise of autism in the United States to use of the MMR. This has been shown to be untrue by rigorous scientific study.

ABNORMAL REACTION TO POLIO VACCINE

Anaphylaxis or anaphylactic shock

NORMAL REACTION TO PREVNAR (PNEUMOCOCCAL VACCINE)

Fever

Signs and tests:

Testing is usually unnecessary.

Treatment:

Treatment depends on the type of symptom observed following immunization. Fever is normally treated with acetaminophen and cool sponge baths. Children with seizures must be seen by a health care provider promptly. Children who develop encephalitis will be hospitalized.

Support Groups:

Expectations (prognosis):

Very few children who receive standard childhood vaccines develop significant problems following immunization. For children who develop problems, standard fever care and a call to the health care provider for reassurance often suffice.

Complications:

Abscess (pus) at site of immunization is a possible complication of vaccination. Other complications are the same as symptoms

Calling your health care provider:

Call your health care provider if you feel that your child is having an adverse reaction to immunizations.

Prevention:

Considering the severity of the diseases that childhood immunizations prevent, the risk of the disease far exceeds the risk of injury from the vaccine. The incidence of vaccine-related injury is extremely low.

The new generation of vaccines produce less fever, less swelling at the site of injection, and fewer vaccine-related conditions. For example, the diphtheria, tetanus, and acellular pertussis (DTaP) vaccine and the inactivated polio vaccine (IPV) currently in use produce fewer side effects than vaccines used against these illnesses in the past.

The Vaccine Adverse Event Reporting System (VAERS) and the National Childhood Vaccine Injury Act were established to track and record reactions to vaccines and help clarify whether there is a consistent pattern of injury associated with a given vaccine.

Physicians are required to record complete information about the vaccines they are using and supply this information to VAERS, along with any reports of injury.