Alternative Names: Angina - stable; Angina - chronic; Angina pectoris

Causes, incidence, and risk factors:

There are approximately�400,000 new cases of stable angina�diagnosed each year, according to the American Heart Association.

The most common cause of angina is coronary artery disease (CAD). Angina pectoris�is the medical term for this type of chest pain.

Situations that increase blood flow to the heart may cause angina in people with CAD. These include exercise, heavy meals, and stress.

The risk factors for angina pectoris include:

• Male gender
• Cigarette smoking
• High cholesterol levels (in particular, high LDL and low HDL cholesterol)
• High blood pressure
• Diabetes
• Family history of coronary heart disease before age 55
• Sedentary lifestyle
• Obesity

Less common causes of angina include:

• Coronary artery spasm (also called Prinzmetal's angina)
• Diseases of the heart valves
• Heart failure
• Abnormal heart rhythms
• Anemia

Symptoms:

Stable angina:

• Occurs after activity, stress, or exertion
• Lasts 1 to 15 minutes
• Is usually relieved�with rest or nitroglycerin

The most common symptom is a�feeling of tightness, heavy pressure, or squeezing or crushing chest pain that:

• Occurs under the breastbone or slightly to the left
• Is not clearly focused in one spot
• May�spread to shoulder, arm, jaw, neck, back, or other areas
• May feel�like gas or indigestion

You should seek medical attention if you have new, unexplained chest pain or pressure. If you have had angina before, call your doctor.

Immediately go to�the hospital if chest pain or heaviness lasts longer than 15 minutes or�is not relieved with medication prescribed by your doctor. The pain�may represent unstable angina or a heart attack.

Signs and tests:

The following tests may be done to diagnose or rule out angina:

• Blood pressure measurement
• Exercise tolerance test (stress test or treadmill test) --�may show ECG changes
• Stress echocardiogram� -- may reveal problems with�the heart's ability to pump blood
• Coronary angiography

Treatment:

The goals of treatment�are to reduce symptoms and prevent complications. If you experience angina pain, you should:

• Rest
• Take nitroglycerin (only if prescribed by your doctor)

There are three primary forms of medication for stable angina.

1. Medications that improve long-term health include aspirin, clopidogrel (Plavix),�and cholesterol-lowering drugs.
2. Medications that improve symptoms include nitrates and calcium channel blowers.
3. Medications that do both include beta blockers and angiotensin-converting enzyme (ACE) inhibitors.

In 2006, the U.S. Food and Drug Administration approved new type of medication called�ranolazine (Ranexa) for the treatment of chronic angina. The drug is for patients who do not respond to traditional angina treatment.�It should be used�in combination with other medicals. Your doctor will tell you which ones.

Your doctor may recommend a cardiac rehabilitation program to help improve your heart's fitness.

Some patients may need surgery such as:

• Percutanueous Transluminal Coronary Angioplasty (PTCA)
• Coronary artery bypass grafting (CABG)

Support Groups:

Expectations (prognosis):

Stable angina usually improves with medication.

Complications:

• Unstable angina
• Heart attack
• Sudden death caused by lethal arrhythmias

Calling your health care provider:

Call your health care provider if any of the following occur:

• Chest pain develops that has not been evaluated
• Your angina changes in frequency, severity, duration, or character (for example, it happens at rest or lasts longer than 15 minutes)
• Your angina requires increasing doses of nitroglycerin

Prevention:

Your doctor may tell you to take nitroglycerin a few minutes in advance if you plan to perform an�activity that may trigger angina pain.

The best prevention for angina is to lower your risk for�coronary heart disease.�

• Stop smoking
• Lose weight if you are overweight
• Control blood pressure, diabetes, and cholesterol

Reducing risk factors may prevent the blockages from getting worse and can reduce their severity, which�reduces angina pain.

References:

U.S. Food and Drug Administration. FDA Approves New Treatment for Chest Pain. Rockville, MD: National Press Office; January 31, 2006. Press Release P06-15.

Zipes DP, Libby P, Bonow RO, Braunwald E, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed. St. Louis, Mo; WB Saunders; 2005: 1281-1308.

Mehta SB. Management of coronary heart disease: stable angina, acute coronary syndrome, myocardial infarction.��Prim Care.� 2005; 32(4): 1057-81.